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  • Writer's pictureSurviving Breast Cancer

Breaking Down Hormone Receptor-Positive Breast Cancer and Treatment

Hormone receptor-positive (HR+) breast cancer accounts for a significant percentage of breast cancer diagnoses, characterized by the presence of hormone receptors—estrogen and progesterone receptors—on cancer cells. Understanding HR+ breast cancer and the latest treatment updates is pivotal in offering tailored therapies for improved outcomes.

Understanding Hormone Receptor-Positive Breast Cancer

HR+ breast cancer is defined by cancer cells having receptors for estrogen, progesterone, or both. These receptors fuel the growth of cancer cells, making HR+ breast cancer sensitive to hormonal therapies.

Diagnosis and Subtyping

Diagnostic Techniques:

  • Immunohistochemistry (IHC) and other laboratory tests detect hormone receptor status.

  • Subtyping HR+ breast cancer helps guide treatment decisions.

Hormonal Therapies: Cornerstone of Treatment

Endocrine Therapy Options:

  • Selective Estrogen Receptor Modulators (SERMs) like tamoxifen block estrogen's effects on cancer cells.

  • Aromatase Inhibitors (AIs) prevent estrogen production in postmenopausal women.

Combination Therapies:

  • Combining hormonal therapies or pairing with targeted agents enhances efficacy.

Latest Treatment Updates

CDK4/6 Inhibitors:

  • CDK4/6 inhibitors (e.g., palbociclib, ribociclib, abemaciclib) are game-changers in HR+ metastatic breast cancer.

  • Combined with hormonal therapies, they significantly prolong progression-free survival.

Extended Endocrine Therapy:

  • Recent studies evaluate the benefit of extended hormonal therapy beyond the standard 5-year duration.

  • Offers potential for reducing recurrence risk in HR+ early-stage breast cancer.

Precision Medicine: Tailoring Treatments

Genomic Profiling:

  • Advancements in genomic testing aid in identifying HR+ breast cancer subtypes and predicting response to treatments.

  • Personalized medicine directs therapies based on individual tumor characteristics.

Challenges and Emerging Research

Resistance Mechanisms:

  • Development of resistance to hormonal therapies remains a challenge.

  • Ongoing research explores mechanisms of resistance and novel treatment strategies.

Immunotherapy in HR+ Breast Cancer:

  • Exploring the role of immunotherapy, including immune checkpoint inhibitors, in HR+ breast cancer treatment.

Management Beyond Treatment

Side Effect Management:

  • Addressing side effects of hormonal therapies, such as hot flashes, bone health issues, and menopausal symptoms.

Patient Support and Survivorship:

  • Importance of patient support programs, survivorship care plans, and psychosocial support for HR+ breast cancer survivors.

Advancements in HR+ Breast Cancer Treatment

The landscape of HR+ breast cancer treatment is continually evolving with innovative therapies and precision medicine approaches. Latest updates in hormonal therapies, combination strategies, and precision medicine offer new avenues for improved outcomes, emphasizing the importance of tailored treatments and ongoing research to combat HR+ breast cancer effectively.


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Meditation Mondays:

Chakra Chanting with Gloria

Mondays at 10:00 a.m. ET 


Thursday Night Thrivers:

All Stages Support Group

Thursdays at 7:00 p.m. ET



Thursday Night Thrivers:

Metastatic Breast Cancer Support Group

First and third Thursdays

of the month at 7:00 p.m. ET



Thursday Night Thrivers:

Inflammatory Breast Cancer Support Group

Second Thursday

of the month at 7:00 p.m. ET


The Caregiver Huddle

Third Tuesday

of the month at 7:00 p.m. ET


Tuesday Night Thrivers

Después de un Diagnóstico:

Grupo de Apoyo en Español

2do y Cuarto Martes de cada mes 

7:00 p.m. ET


Encourage and Empower

For Newly Diagnosed

September 10, 11:00 a.m. ET


Breast Cancer Book Club

The first Sunday of the month



June 14,  11:30 a.m. ET


Restorative Yoga:

Unearthing Opportunities

June 17 ,  5:30 p.m. ET


The Sun's Embrace: A Summer Solstice Meditation

June 21,  11:00 a.m. ET


Qi Gong

June 25,  11:30 a.m. ET


Art Therapy

July 1, 6:00 p.m. ET


Forest Bathing

July 2,  6:00 p.m. ET


Yoga Fitness with Chair Assist

July 9, 11:30 a.m. ET


Yoga Stretching for DIEP flap

July 9,  6:00 p.m. ET


Reflect & Recharge

Expressive Writing

July 22,  6:00 p.m. ET


Más eventos en español


Upcoming Events


Surviving Breast Cancer provides breast cancer support, events, and webinars at no cost to you! Whether you are looking to gain more knowledge on a particular topic or meet up with other breast cancer survivors, we have something for everyone. 


Our standing appointment on Thursdays is for all stages. We also host specific breakout groups once a month for specific stages and subtypes such as Metastatic breast cancer, and Inflammatory Breast Cancer, etc. 


The Book Club meets the first Sunday of every month at 11 am ET. You are welcome to join each month or pick and choose your month based on your availability and the book we are reading. 


Through art, writing, and other creative modalities, we hold the power to manage our stress, make sense of our now, and relax into moments of stillness. 


Free, monthly, online classes in restorative yoga, yoga for breast cancer, and Zumba. 


Después de un Diagnóstico

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